Individuals with a mental disorder often have a co-existing condition, such as depression, anxiety, or often, a substance use disorder. Alcohol or drugs are frequently used to medicate the symptoms of a mental disorder. But the presence of a substance use disorder can make treatment more complicated and can delay the reduction in symptoms.

Altered Mismatch Negativity

In an article appearing in Clinical Psychiatry News, researchers in Australia examined the impact of risky alcohol consumption among those with bipolar disorder, as compared with nondrinkers. The study found that there was a phenomenon known as “altered mismatch negativity” on electroencephalography (EEG) exams among those with risky drinking histories.

According to the article, mismatch negativity is the brain’s automatic electrical activity that responds to auditory stimulation when there is a change in sounds. When there is a reduction in mismatch negativity, it indicates an impairment of NMDA-receptor activation. The NMDA receptors were already thought to be impacted by both alcohol use and in patients with bipolar disorder.

To measure the mismatch negativity in individuals with risky alcohol use and bipolar disorder, the researchers recruited 42 bipolar disorder patients and 34 control subjects. The participants were between the ages of 16 and 30. The participants were subjected to EEG exams with auditory stimuli.

Among the participants, 16 bipolar patients engaged in risky alcohol-related behaviors, as well as 14 of the control subjects. Of the remaining patients, 26 of the bipolar subjects and 20 of the control subjects did not engage in risky drinking.

Misuse Of Alcohol In Those Who Are Bipolar

The researchers found that the misuse of alcohol was a strong predictor of attenuations in mismatch negativity. The effect was significantly more profound among those diagnosed with bipolar disorder. The researchers believe that the alcohol may play an antagonistic role on the NMDA/glutamatergic system. This is consistent with the growing use of glutamatergic agents to treat bipolar disorder. Limiting alcohol consumption may be an important step when beginning treatment with glutamatergic agents.

The article notes recent studies showing that bipolar males between the ages of 20 and 30 have the highest weekly substance use. In more general terms, those who are diagnosed with bipolar disorder before adulthood have lifetime alcohol use rates of up to 70 percent.

The researchers note multiple potential limitations on their findings. For instance, the youths included in the study are not able to legally buy alcohol in Australia, so the underage drinkers may have had incentive to understate drinking behavior.

The study adds to the body of evidence that shows that bipolar disorder patients are particularly susceptible to the dangers of risky alcohol consumption.

Discover Why Integrating Medical And Mental Health Treatment Is Crucial

Depression can be a very serious mental health condition. People struggle with depression to varying degrees. For some it is a lifelong battle, while for others it comes on as the result of life situations but is temporary. In any type of depression, self-medication is common but ill advised. Self-medication is the use of drugs or alcohol to mitigate symptoms. It is a dangerous and destructive practice, but not everyone who does it realizes the harm they are causing. If you or someone you love struggles with depression, look out for and avoid self-medicating.

Depression And Substance Abuse

Self-medicating is particularly common for depression. It mostly occurs in people who have not been diagnosed and are not getting professional treatment for depression. If you feel depressed, it is natural to turn to something that will either make you feel better, or that will at least numb that bad feeling. Most people reach for alcohol, but prescription drugs and illegal drugs are used as well for the self-medication of depression. The rates of substance abuse among people with either depression or anxiety are as high as 20 percent.

The Dangers Of Self-Medicating

Self-medicating feelings of depression often work in the short term. It’s why so many people resort to it as a strategy for feeling better. Over a long period of time, however, doing so only causes more problems. Not least of these problems is the possibility of addiction. A dual diagnosis of depression and addiction is not uncommon. Relying on alcohol or drugs to make you feel better is a habit that leads to dependence. Your body will get used to the substance and you will find it difficult to quit.

Another problem with self-medicating is that it never allows you to confront and deal with your depression. Drinking or using drugs is like a quick fix, but one that doesn’t last. It is not a permanent solution to your problems. Only treatment by health care professionals using therapy in combination with appropriate medication will provide you with lasting relief. In fact, research into teenage depression has found that self-medication can actually make a mental illness more serious.

How Can I Tell If Someone Is Self-Medicating?

If you’re worried that someone you care about may be struggling with depression and is self-medicating, act immediately. Be there for your loved one and offer your help. People often don’t realize that they are depressed. It is usually easier for others to see the signs.

First look for signs of depression:

• Feelings of hopelessness or loneliness
• Apathy
• Changes in sleeping habits
• Weight loss or gain
• Irritability or irrational anger
• Difficulty concentrating
• Reckless behaviors
• Unexplained aches and pains

If, in addition to seeing these signs in someone, you also see them using drugs or alcohol frequently or to excess, he or she is probably self-medicating for depression. Your loved one may try to hide drug use or drinking, which is another clear sign. Confront this person as soon as you can, but do so in a loving and compassionate manner and offer your help.

Depression is a complex mental illness. It afflicts many people, who often turn to substances for relief. Instead of drugging the problem, get help for yourself or your loved one. The care and treatment given by professionals is the right solution to coping with and living with depression. Self-medicating may feel right initially, but the good feeling won’t last. It will only make the condition and symptoms worse.

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