Cocaine is well known for its ability to trigger drastic changes in the normal cardiovascular (heart and blood vessel) health of its users. However, people who use/abuse the drug can also develop a range of problems in the gastrointestinal (GI) tract, which extends from the esophagus to the rectum. Some of these problems occur relatively frequently, but only produce relatively minor health complications. Other cocaine-related gastrointestinal problems occur relatively rarely, but can produce severe or even life-threatening health complications. These advanced complications occur when cocaine use leads to loss of normal blood flow to various parts of the GI tract.

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